Aerobic gram-negative bacilli (143 of 266 ) and Candida species (75 of 266 ) were the most common microorganisms. There were 138 independent new BSIs, of which 68 (49.3%) were polymicrobial and 266 were unique isolates. Results The analysis identified 420 unique episodes of infective endocarditis in 309 PWID (mean patient age, 35.7 years 213 episodes involving male patients), with 82 (19.5%) complicated by new BSIs. Main Outcomes and Measures New BSIs and factors associated with their development, treatment setting of infective endocarditis episodes (ie, inpatient vs outpatient), and 90-day mortality. Data were analyzed from April 1, 2007, to June 29, 2018. Participants included a consecutive sample of all PWID 18 years or older admitted with infective endocarditis. Objectives To characterize new BSIs in PWID receiving treatment for infective endocarditis, to determine the clinical factors associated with their development, and to determine whether new BSIs and treatment setting are associated with mortality.ĭesign, Setting, and Participants This retrospective cohort study was performed at 3 tertiary care hospitals in London, Ontario, Canada, from April 1, 2007, to March 31, 2018. Importance People who inject drugs (PWID) who are being treated for infective endocarditis remain at risk of new bloodstream infections (BSIs) due to ongoing intravenous drug use (IVDU).
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Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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